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doi: 10.2174/1389203720666190722152415 154 SuH.HuangJ.WengS.ZhangB.ZhangT.XuY

Br J Exp Pathol 68:189199 Mar M, Bai J, Cederbaum AI (2002) Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria

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As a result, downstream targets of the PGC-1/ERR pathway, including NRF1, TFAM, and mitochondrial-encoded electron transport chain subunits, show reduced expression, leading to controlled suppression of mitochondrial biogenesis ( This regulation is relevant in EMs, where increased mitochondrial biogenesis contributes to oxidative stress, altered metabolic activity, and lesion growth